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. 2024 Feb 28;627(8004):646–655. doi: 10.1038/s41586-024-07121-9

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© The Authors 2024 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — Top, To understand the mechanism(s) of response with tiragolumab in combination with atezolizumab, we leveraged samples collected from CITYSCAPE (left; NSCLC, Ph2) including tumour pretreatment samples for bulk RNA-seq and multiplex immunofluorescence (mIF), and pretreatment and on-treatment serum samples for Mass Spec, GO30103 (middle; NSCLC, Ph1b) including pretreatment and on-treatment peripheral blood mononuclear cells (PMBC) for single cell RNA-seq, and preclinical models (right). Bottom, Anti-TIGIT antibody, in a Fc dependent manner, remodels immunosuppressive tumour microenvironments by leveraging myeloid cells and Tregs, which was further enhanced with the addition of anti-PD-(L)1 antibody. Created with BioRender.com.