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. 2024 May 30;15:4605. doi: 10.1038/s41467-024-48220-5

Fig. 2. IRF3 promotes insulin resistance in cultured mouse and human adipocytes.

Fig. 2

a Glucose uptake in mouse adipocytes expressing GFP or constitutively active IRF3-2D mutant (n = 8). b Western blot of pAKT (S473) and IRF3 in WT and FI3OE SVF-derived adipocytes treated with control or 100 nM insulin. c, Glucose uptake (n = 6) in WT and FI3OE SVF-derived adipocytes treated with vehicle or 100 nM insulin. d Western blot of pAKT (S473) and IRF3 in human SGBS adipocytes transduced with lentivirus expressing GFP or IRF3-2D. e Glucose uptake in human SGBS adipocytes expressing GFP or IRF3-2D mutant (n = 8). Statistical significance was assessed by two-way ANOVA. Data are expressed as mean ± SEM.