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. 2024 May 30;15:4605. doi: 10.1038/s41467-024-48220-5

Fig. 4. Adipocyte IRF3 promotes HFD-induced insulin resistance at thermoneutrality.

Fig. 4

Metabolic analysis of male WT and FI3OE mice (n = 10) after 16 weeks of HFD feeding at thermoneutrality, including insulin tolerance test (a), glucose tolerance test (b), serum insulin levels (c), immunoblotting for pAKT (S473) protein levels in eWAT, BAT, iWAT, muscle and liver (d), in vivo 2-deoxyglucose uptake in BAT, iWAT, eWAT, quadriceps muscle, and heart (e). Statistical significance was assessed by two-way ANOVA (a–c) or two-tailed Student’s t test (d, e). Data in all panels are expressed as mean ± SEM.