Skip to main content
. 2024 May 30;15:4605. doi: 10.1038/s41467-024-48220-5

Fig. 8. Pharmacologically inhibiting AIG1 attenuates HFD-induced insulin resistance in FI3OE mice.

Fig. 8

a Proposed mechanism of covalent AIG1 inhibition by ABD-110. b Schematic illustrating the strategy for the AIG1 inhibitor treatment of WT and FI3OE mice on HFD at thermoneutrality. Figure created with Biorender.com. Insulin tolerance test (c), glucose tolerance test (d), serum insulin levels (e), in vivo 2-deoxyglucose uptake in BAT, iWAT, eWAT, quadriceps muscle, and heart (f) of mice described in (b) (n = 7–8). g Quantification of FAHFA levels in WT and FI3OE SVF-derived adipocytes treated with or without ABD-110 (1 μM, 4 h) (n = 12). Statistical significance was assessed by two-way ANOVA. Data in all panels are expressed as mean ± SEM. *P < 0.05 vs WT, #P < 0.05 vs vehicle.