TABLE 1.
Maternal and fetal blood gases, Hb and lactate values prior to anaesthesia for MRI and during Basal and TAD periods.
| Pre‐anaesthesia (n = 7) | Basal (n = 7) | TAD 1 (15–65 min post‐tadalafil) (n = 7) | TAD 2 (75–135 min post‐tadalafil) (n = 7) | P | |
|---|---|---|---|---|---|
| Maternal venous parameters | |||||
| Tadalafil (ng/mL) | — | — | 1270 ± 740 | 318 ± 108 | 0.016 |
| (mmHg) | 40.8 ± 7.1 a | 64.3 ± 9.0 b | 67.2 ± 9.9 b | 73.5 ± 7.5 b | <0.0001 |
| (mmHg) | 40.6 ± 4.3 | 41.7 ± 5.3 | 45.2 ± 7.4 | 45.2 ± 7.1 | 0.191 |
| pH | 7.444 ± 0.024 a | 7.387 ± 0.038 b | 7.374 ± 0.044 b | 7.372 ± 0.041 b | 0.035 |
| (%) | 68.4 ± 8.1 a | 87.2 ± 2.5 b | 87.8 ± 4.4 b | 90.6 ± 3.2 b | 0.002 |
| Hb (g/L) | 111.7 ± 7.5 a | 80.2 ± 8.0 b | 83.1 ± 7.4 b | 83.3 ± 8.5 b | <0.0001 |
| Hct (%) | 33 ± 2 a | 24 ± 2 b | 25 ± 2 b | 25 ± 3 b | <0.0001 |
| Lactate (mmol/L) | 1.01 ± 0.66 | 0.88 ± 0.29 | 0.88 ± 0.23 | 0.86 ± 0.20 | 0.635 |
| Fetal arterial parameters | |||||
| Tadalafil (ng/mL) | — | — | 74 ± 16 | 62 ± 21 | ns |
| (mmHg) | 19.5 ± 1.9 | 20.9 ± 2.9 | 19.0 ± 3.3 | 18.7 ± 3.1 | 0.198 |
| (mmHg) | 45.9 ± 4.7 a | 56.1 ± 6.3 b | 61.2 ± 7.1 c | 63.8 ± 5.8 c | 0.002 |
| pH | 7.392 ± 0.025 a | 7.308 ± 0.037 b | 7.293 ± 0.025 b | 7.292 ± 0.023 b | 0.001 |
| (%) | 65.9 ± 5.0 | 62.4 ± 5.6 | 54.8 ± 10.0 | 53.9 ± 10.0 | 0.125 |
| Hb (g/L) | 104.5 ± 8.6 | 94.7 ± 6.3 | 98.9 ± 5.6 | 98.4 ± 5.6 | 0.160 |
| Hct (%) | 29 ± 2 | 28 ± 2 | 29 ± 2 | 29 ± 2 | 0.153 |
| Lactate (mmol/L) | 1.40 ± 0.11 a | 1.67 ± 0.30 a | 2.08 ± 0.39 b | 2.32 ± 0.39 b | 0.001 |
Note: Values are means ± SD. Data analysed by repeated measures one‐way ANOVA with Bonferroni's correction for multiple comparisons. ns, P > 0.05. Superscript letters indicate significant differences between time points (P < 0.05) such that values with different letters are statistically different from each other and values with the same letter are not different. The difference between plasma tadalafil concentrations in the TAD 1 and TAD 2 period was determined by a paired t‐test. P‐values shown in italic are significant (P < 0.05).