Table 4.

Association between histological finding and fasting insulin concentration, or HOMA-IR

Variable	Fibrosis stage 0–2 (n=174)	Fibrosis stage 3–4 (n=106)	P value	NAS 1–4 (n=127)	NAS 5–8 (n=153)	P value
Insulin, μU/mL	11.7 (7.2–16.3)	17.1 (12.6–26.4)	<0.01	11.0 (6.9–16)	15.4 (11.6–23.9)	<0.01
HOMA-IR	2.96 (1.88–4.76)	5.30 (3.46–7.64)	<0.01	2.83 (1.68–4.51)	4.71 (2.94–7.07)	<0.01

Values are presented as median (interquartile range). To evaluate between-group differences, the Mann-Whitney U test was used for continuous variables. P<0.05 was considered significant.

HOMA-IR, homeostasis model assessment of insulin resistance; NAS, NAFLD activity score.