A, Microsimulation model. The oval “Overdose” state represents a tunnel state; solid lines, transitions among health states; dotted lines, transitions between health states and overdose; and arrows, possible directions for state transitions. B, Decision tree model. We defined the overdose settings according to prior studies by the Rhode Island Department of Health,18,19 where private settings include apartment or residence; semiprivate settings include hotel, motel, shelter, nursing home, hospital, prison, group home, assisted living, or treatment facility; and public settings include theater, concert, show, office, park, school, bar or restaurant, roadway, or cemetery. EMS indicates emergency medical services.