Table 1.
Patient and treatment characteristics of 3252 Swedish patients treated with anterior resection and ileostomy for rectal cancer between 2007 and 2016
| Exposed N = 1173 |
Unexposed N = 2079 |
P | |
|---|---|---|---|
| Sex | <0.001 | ||
| Male | 776 (66.2) | 1201 (57.8) | |
| Female | 397 (33.8) | 878 (42.2) | |
| Country of birth | 0.801 | ||
| Sweden | 993 (84.7) | 1751(84.2) | |
| Other | 180 (15.4) | 327 (15.7) | |
| Missing | 0 (0.0) | 1 (0.1) | |
| Age at cancer diagnosis (years) | 70 (64–75) | 65 (57–71) | <0.001 |
| Age (years) | <0.001 | ||
| <55 | 58 (4.9) | 381 (18.3) | |
| 55–65 | 249 (21.2) | 609 (29.3) | |
| 65–75 | 549 (46.8) | 799 (38.4) | |
| >75 | 317 (27.0) | 290 (14.0) | |
| BMI (kg/m2) | 26.3 (24.2–29.2) | 25.2 (23.0–27.7) | <0.001 |
| BMI (kg/m2) | <0.001 | ||
| <18.5 | 11 (0.9) | 30 (1.4) | |
| 18.5–24.9 | 369 (31.5) | 914 (44.0) | |
| 25.0–29.9 | 508 (43.3) | 811 (39.0) | |
| >30 | 237 (20.2) | 248 (11.9) | |
| Missing | 48 (4.1) | 76 (3.7) | |
| ASA classification | <0.001 | ||
| ASA 1 | 39 (3.3) | 803 (38.6) | |
| ASA 2 | 826 (70.4) | 1062 (51.1) | |
| ASA 3 + 4 | 296 (25.2) | 179 (8.6) | |
| Missing | 12 (1.0) | 35 (1.7) | |
| CCI score | <0.001 | ||
| 0 | 738 (62.9) | 1670 (80.3) | |
| 1 | 164 (14.0) | 113 (5.4) | |
| 2 | 169 (14.4) | 234 (11.3) | |
| >=3 | 92 (7.8) | 45 (2.2) | |
| Missing | 10 (0.9) | 17 (0.8) | |
| Diagnosis of cardiovascular disease | <0.001 | ||
| No | 382 (32.6) | 1796 (86.4) | |
| Yes | 791 (67.4) | 283 (13.6) | |
| Diagnosis of diabetes mellitus | <0.001 | ||
| No | 976 (83.2) | 1985 (95.5) | |
| Yes | 197 (16.8) | 94 (4.5) | |
| Preoperative radiotherapy | <0.001 | ||
| No | 437 (37.3) | 646 (31.1) | |
| Yes | 736 (62.8) | 1433 (68.9) | |
| Length of index surgery (min) | 257 (206–240) | 254 (200–326) | 0.057 |
| Perioperative bleeding index surgery (ml) | 380 (200–650) | 300 (150–600) | <0.001 |
| Time from index surgery to discharge of index admission (days) | 10 (7–15) | 9 (7–14) | <0.001 |
| Pathological TNM stage | 0.466 | ||
| 1 | 398 (33.9) | 682 (32.8) | |
| 2 | 347 (29.6) | 584 (28.1) | |
| 3 | 420 (35.8) | 801 (38.5) | |
| 4 | 6 (0.5) | 9 (0.4) | |
| Missing | 2 (0.2) | 3 (0.1) | |
| Postoperative chemotherapy | <0.001 | ||
| No | 929 (79.2) | 1499 (72.1) | |
| Yes | 244 (20.8) | 580 (27.9) |
Continuous variables reported as median (i.q.r.) and categorical variables as frequency (proportion). Exposed defined as having at least two dispensations of ACEI, ARB or diuretics within a time period of 365 days prior to index surgery. P calculated using Fisher’s exact test or Wilcoxon rank sum-test. ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin II receptor blockers; CCI, Charlson Comorbidity Index (weighted).