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. 2023 Nov 30;109(6):1726–1740. doi: 10.3324/haematol.2023.283559

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Figure 5. — Acute lymphoblastic leukemia from mutant IL7Rα and mutNRAS has similar phenotype to mutant IL7Rα and over-expressed MYC. RAG1^-/- mice were injected with thymocytes transduced with either mutIL7R and mutNRAS or with mutIL7R and MYC. After 16-21 days from injection, spleen was harvested from mice (N=7) and analyzed by flow cytometry as follows: all markers’ expression is from either GFP or GFP and mCherry (double positive) gated thymocytes. (A) CD4 versus CD8 (B) TCRVα2 versus TCRβ (C) TCRβ versus TCRy/δ.