Skip to main content
. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Immunol Rev. 2023 Jul 16;320(1):58–82. doi: 10.1111/imr.13233

Figure 3. Characteristics of new hybrid T-cell formats.

Figure 3.

(left). Ab-TCR is a new TCR/CAR-T format, which consists of two separate activation domains: the first domain uses a Fab specific for a tumor antigen, linked to gamma/delta TCR to facilitate a natural T-cell activation. The second domain uses a scFv of an mAb targeting a second tumor antigen, linked to a costimulatory molecule, CD28, down-stream of a signaling molecule needed to for fully activate T-cells and duel targeting tumor antigens This new format of CAR-T-cells could avoid excessive synthetic activation and toxicity caused by traditional CAR-T-cells that assemble T-cell activation molecules in one construct. (right). TCRm CAR-T-cells use traditional CAR-T construct, however, they are able to target intracellular tumor antigen-derived peptide/MHC complexes, by using scFv derived from TCR mimic mAbs. CSR: Costimulatory signaling receptor. All figures were created by using BioRender.