Figure 5. Effects of 150 kHz TTFields versus control (heat) on neurologic functional status milestones in mice bearing spinal tumors.

Mice demonstrating normal posture (A) and progressive paralysis milestones of tail drop (B), dorsal stepping (C), hind limb sweeping (D and E), and hind limb paralysis (F). Control mice displayed a median time-to-tail drop of 17 postoperative days and all others experienced tail drop by 20 days after implantation, whereas 53% of TTFields-exposed mice displayed symptoms on day 33 and the other 47% remained symptom free (G). Control mice had a median time-to–dorsal stepping of 25 days, while 2 of 15 TTFields-exposed mice displayed dorsal stepping over the observation period (on days 27 and 33) (H). Control mice had median time-to–hind limb sweeping at 31.5 days and median time-to–bilateral hind limb paralysis at 35.5 days; in contrast, no TTFields-exposed mice progressed to either of these milestones by the end of the observation period (I and J). Statistical comparison of asymptomatic fractions performed using log-rank (Mantel-Cox) test (n = 5 treated animals and 3 control animals, per experiment).