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. 2024 Apr 23;9(10):e169738. doi: 10.1172/jci.insight.169738

Figure 2. Slc39a14 deficiency corrects liver Epo excess and polycythemia in Slc30a10–/– mice.

Figure 2

Five-week-old Slc30a10 Slc39a14 mice were analyzed for liver Mn levels by ICP-OES (A); liver Epo (B), Serpine1 (C), Hk2 (D), and Anxa2 (E) RNA levels by qPCR; and RBC counts (F), hemoglobin levels (G), and hematocrits (H) by complete blood counts. Data are represented as means ± standard deviation, with at least 5 animals per group. Data were tested for normal distribution by Shapiro-Wilk test; if not normally distributed, data were log-transformed. Groups within each sex were compared by 2-way ANOVA with Tukey’s multiple comparisons test. (** P < 0.01, *** P < 0.001, **** P < 0.0001.)