Fig 2. Proteins that contain pockets structurally suited to binding drug-like small molecules.

The surfaces of potential binding pockets are depicted, as are ribbon structures of proximal portions of the protein. The proteins are: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr; Dxr1 [magenta] and Dxr2 [green] binding pockets), ß-ketoacyl acyl carrier protein reductase (FabG), 3-phosphoshikimate 1-carboxyvinyltransferase (EPSP synthase), dihydrofolate synthase (FolC; FolC1 [orange] and FolC2 [light green] binding pockets), hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and glucose-1-Phosphate Thymidylyltransferase (TYLT).