Table 2.

Compounds with desirable efficacy ratios at 40 micromolar

	ratio of cancer cell colonies to bone marrow colonies at 8 days*
cell line	Dxr2-017	Dxr2-055	Dxr2-069	FolC2-001	FolC2-005	FolC2-044	FolC1-042	FolC1-020	Dxr1-021	TYLT-072
HT116	0.08	0.63	0.93	0.60	0.70	0.03	0.51	0.23	0.95	1.18
HT29	0.00	0.00	0.01	0.79	0.06	0.00	0.10	0.12	0.59	2.05
MCF-7	0.02	0.04	0.03	0.43	0.33	0.01	0.64	0.01	0.81	0.98
MDAMB231	0.00	0.05	0.59	0.28	0.78	0.16	0.65	0.65	0.62	0.97
H226	0.02	0.10	0.03	0.00	0.11	0.00	0.01	0.26	1.26	0.14
A549	0.07	0.96	0.15	0.53	0.69	0.15	0.96	0.89	0.72	1.17
PC3-M	0.00	0.00	0.00	0.41	0.00	0.00	0.18	0.13	0.38	0.99
LNCaP**	0.05	0.40	-	0.34	0.28	-	-	-	-	-
relative activity for a given compound, % ¥	100	75	71	63	63	100	43	73	14	14

^*efficacy ratios of <0.5 denoted in blue font

^**LNCaP cells only examined as determined by additional supporting data, as denoted

^¥denotes % of cells tested where ratio is <0.5