Figure 5: Cherry-picked designs for Guanine riboswitch aptamer (PDB: 4FE5).

We show the RhoFold-predicted 3D structure in colour overlaid on the groundtruth structure in grey. Designs recover the base pairing patterns and tertiary structure of the RNA, as measured by high self-consistency score. gRNAde’s perplexity is correlated well with 3D self-consistency scores and can be useful for ranking designs. More design visualisations are available in Appendix A.