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[Preprint]. 2024 May 25:2024.03.31.587283. [Version 2] doi: 10.1101/2024.03.31.587283

Table 2:

Full results for Figure 4 comparing gRNAde to Rosetta, FARNA and ViennaRNA for single-state design on 14 RNA structures of interest identified by Das et al. [2010]. Rosetta and FARNA recovery values are taken from Das et al. [2010], Supplementary Table 2.

PDB ID Description ViennaRNA
Recovery
FARNA
Recovery
Rosetta
Recovery
gRNAde (single-state)
Recovery Perplexity 2D self-cons.

1CSL RRE high affinity site 0.25 0.20 0.44 0.5719 1.2812 0.8644
1ET4 Vitamin B12 binding RNA aptamer 0.25 0.34 0.44 0.6250 1.3457 −0.0135
1F27 Biotin-binding RNA pseudoknot 0.30 0.36 0.37 0.3437 1.6203 0.4523
1L2X Viral RNA pseudoknot 0.24 0.45 0.48 0.4721 1.3181 0.5692
1LNT RNA internal loop of SRP 0.33 0.27 0.53 0.5843 1.4337 0.1379
1Q9A Sarcin/ricin domain from E.coli 23S rRNA 0.27 0.40 0.41 0.5044 1.3411 0.0597
4FE5 Guanine riboswitch aptamer 0.29 0.28 0.36 0.5300 1.3824 0.9116
1X9C All-RNA hairpin ribozyme 0.26 0.31 0.50 0.5000 1.3905 0.6630
1XPE HIV-1 B RNA dimerization initiation site 0.27 0.24 0.40 0.7037 1.2177 0.7768
2GCS Pre-cleavage state of glmS ribozyme 0.25 0.26 0.44 0.5078 1.3053 0.4062
2GDI Thiamine pyrophosphate-specific riboswitch 0.25 0.38 0.48 0.6500 1.2363 −0.0251
2OEU Junctionless hairpin ribozyme 0.23 0.30 0.37 0.9519 1.0913 0.7768
2R8S Tetrahymena ribozyme P4-P6 domain 0.27 0.36 0.53 0.5689 1.1881 0.7281
354D Loop E from E. coli 5S rRNA 0.28 0.35 0.55 0.4410 1.4938 0.0430

Overall recovery: 0.27 0.32 0.45 0.5682