Figure 1: The gRNAde pipeline for 3D RNA inverse design.

gRNAde is a generative model for RNA sequence design conditioned on backbone 3D structure(s). gRNAde processes one or more RNA backbone graphs (a conformational ensemble) via a multi-state GNN encoder which is equivariant to 3D roto-translation of coordinates as well as conformational state order, followed by conformational state order-invariant pooling and autoregressive sequence decoding.