Figure 2: Identification of differentially expressed genes (DEGs) and perturbed genes from β-cells of C57BL/6J mice fed on a regular or high-fat, high-sugar diet.

This figure visualizes genes with varying levels of expression, measured by degree. (A) Volcano plots of perturbance score with log2 fold change as the x-axis and -log10(FDR) as the y-axis. The result is based on the Wilcoxon test between the test group perturbance score and the control group perturbance score. (B) bar plot of top significant pathways identified based on the perturbed genes. (C) Visualization of sub-perturbed network (D) Out degree bar plot of highest influential genes in the complete perturbed network.