Table 4. Amyloid+ MCI and Amyloid— CU comparison in the test set.

The volumes of hippocampus subfields and median thicknesses of cortical subregions of 65 Amyloid— CU and 18 Amyloid+ MCI participants were calculated separately based on the segmentation results of single-modality and multi-modality models. The volumes of subfields were adjusted for the hippocampal tail. p-value, AUC and Cohen's D of multi-modality model and single-modality model were compared. For each subregion, if the p-value of one of the two models was less than 0.05, the smaller p-value as well as the larger AUC and Cohen's D were marked bold. (MCI: mild cognitive impairment; CU: cognitively unimpaired; AUC: area under the ROC curve)

			Single-modality Model			Multi-modality Model
Side	Measure	Subregion	p-value	AUC	Cohen’D	p-value	AUC	Cohen’s D
Left	Adjusted Volume	CA1	0.047	0.73	0.48	0.00040	0.75	0.86
		CA2	0.0098	0.69	0.78	3.0E-05	0.78	1.25
		CA3	0.38	0.58	0.23	0.00029	0.76	0.93
		DG	0.057	0.71	0.49	7.4E-05	0.78	0.99
		SUB	0.080	0.73	0.48	0.00010	0.76	0.89
	Median Thickness	ERC	0.43	0.50	0.24	0.033	0.65	0.67
		BA35	0.61	0.49	0.09	0.39	0.51	0.30
		BA36	0.28	0.41	0.26	0.71	0.46	0.01
		PHC	0.37	0.39	0.28	0.66	0.50	0.16
Right	Adjusted Volume	CA1	0.033	0.66	0.46	0.0012	0.72	0.66
		CA2	0.043	0.69	0.60	0.00062	0.77	0.94
		CA3	0.45	0.62	0.15	0.026	0.67	0.48
		DG	0.013	0.71	0.63	0.0010	0.73	0.78
		SUB	0.012	0.68	0.56	0.0036	0.69	0.64
	Median Thickness	ERC	0.45	0.47	0.16	0.21	0.58	0.42
		BA35	0.71	0.48	0.04	0.21	0.58	0.44
		BA36	0.54	0.45	0.10	0.91	0.52	0.14
		PHC	0.38	0.43	0.24	0.68	0.52	0.14