Table 2: Significant p values from two-way ANOVA (genotype x treatment) for male P30 CX-4945-treated Ts65Dn trabecular and cortical parameters and body weight.

All effect and interaction p values reported are adjusted using the Benjamini-Hochberg method.

	BMD	BV/TV	Tb.Th	Tb.Spǂ	Tb.N		Average Weight		Weight Gain
Genotype Effect	0.008	0.008	NS	0.008	0.008		<0.001		NS
Treatment Effect	NS	NS	NS	NS	NS		NS		NS
Interaction	NS	NS	NS	NS	NS		NS		NS
	Tt.Ar	Ma.Ar	Ct.Ar	Ct.Th	Ps.Pm	Ec.Pm	Imax	Imin	Ct.TMD
Genotype Effect	0.005	0.005	0.005	0.005	0.005	0.005	0.005	0.005	0.005
Treatment Effect	NS	NS	NS	NS	NS	NS	NS	NS	NS
Interaction	NS	NS	NS	NS	NS	NS	NS	NS	NS

^ǂindicates the data was log-transformed for statistical analysis due to non-normal distribution. NS indicates p value was not significant. Vehicle-treated euploid (n = 10), CX-4945-treated euploid (n = 13), vehicle-treated Ts65Dn (n = 13), CX-4945-treated Ts65Dn (n = 8).