Table 1.
Prioritised rs-fMRI traits.
| P-value | |||||
|---|---|---|---|---|---|
| edge_pheno262 | Pair 7–11 | (Frontal|Cingulate) & (Angular|Temporal) | LAVA (local) | 0.49 | 1.67E-04 |
| node_pheno17 | Node 17 | Temporal | LAVA (local) | 0.44 | 2.11E-04 |
| edge_pheno262 | Pair 7–11 | (Frontal|Cingulate) & (Angular|Temporal) | MR (IVW lenient) | −0.34 | 9.75E-12 |
| edge_pheno1142 | Pair 29–44 | Parietal & Frontal_Inf | MR (IVW lenient) | 0.24 | 1.14E-06 |
| edge_pheno816 | Pair 11–36 | (Angular|Temporal) & Precuneus | MR (IVW lenient) | −0.17 | 3.15E-06 |
| edge_pheno491 | Pair 5–25 | (Precuneus|Angular|Cingulate) & (Frontal|Precentral) | MR (IVW lenient) | −0.17 | 4.91E-06 |
| edge_pheno1698 | ICA 3 | Global measure | MR (IVW lenient) | −0.22 | 1.80E-05 |
| edge_pheno1205 | Pair 5–46 | (Precuneus|Angular|Cingulate) & Temporal | MR (IVW lenient) | 0.18 | 2.18E-05 |
| edge_pheno253 | Pair 7–10 | (Frontal|Cingulate) & (OccipitalPrecuneus) | MR (IVW lenient) | 0.16 | 2.92E-05 |
| node_pheno17 | Node 17 | Temporal | MR (IVW lenient) | 0.18 | 1.01E-04* |
| edge_pheno249 | Pair 3–10 | (Lingual|Fusiform) & (OccipitalPrecuneus) | MR (IVW lenient) | −0.16 | 1.35E-04 |
| edge_pheno593 | Pair 5–29 | (Precuneus|Angular|Cingulate) & Parietal | MR (IVW lenient) | −0.15 | 2.61E-04 |
| edge_pheno1359 | Pair 21–49 | Frontal_Sup & (Temporal_Mid|Angular) | MR (IVW lenient) | 0.14 | 3.70E-04 |
| edge_pheno286 | Pair 10–13 | (OccipitalPrecuneus) & Frontal_Sup | MR (IVW lenient) | 0.14 | 4.63E-04 |
The rs-fMRI traits significantly locally genetically correlated with sociability (LAVA, see Table S4 for further details) or with significant MR evidence for sociability (Table S5), both after correction for multiple testing. Two traits with significant MR IVW p-values but evidence for pleiotropy are not shown. Effect size for LAVA: correlation r2; effect size for MR: IVW beta. The table shows uncorrected p-values.
*
Significant MR-Egger intercept p-value (indicating pleiotropy). The trait is shown nevertheless, because it also has significant local genetic correlation evidence through LAVA.