Date of diagnosis of localized breast cancer patients (N = 187) included in the PAPESCO-19 prospective study. Lockd.–Lockdown, InclStrt–start of study inclusion, InclEnd–end of study inclusion; Cranberry zones with solid contour– 1st and 2nd French national Lockdowns (from March 17 to May 11, 2020 and from October 30 to December 15, 2020, respectively). Lime zone delimited by dashes: inclusion period of the PAPESCO-19 study. Vertical dash lines: the first day of 2019, 2020 and 2021. Black circle: Nantes, Blue square: Angers; Red triangle: Clermont-Ferrand; Green diamond: Nancy; Vertical jitter has been added to reduce scatters from overlapping.