Table 4.

First 20 pathways based on P value for downregulated genes

Genes	Pathways
HIST1H2BK POLR2K HIST2H2AB TWISTNB	RNA polymerase I chain elongation
RFC3 HIST1H2BK HIST2H2AB	Telomere maintenance
HIST1H2BK POLR2K HIST2H2AB TWISTNB	Nucleolar remodeling complex negatively regulates ribosomal RNA (rRNA) expression
HIST1H2BK HIST2H2AB	Packaging of telomere ends
HIST1H2BK HIST2H2AB	RNA polymerase I promoter opening
HIST1H2BK POLR2K HIST2H2AB TWISTNB	RNA polymerase I promoter clearance
HIST1H2BK POLR2K HIST2H2AB TWISTNB	RNA polymerase I transcription
HIST1H2BK HIST2H2AB	DNA methylation
HIST1H2BK POLR2K HIST2H2AB TWISTNB	Negative epigenetic regulation of rRNA expression
HIST1H2BK HIST2H2AB	Formation of the beta-catenin: tansactivation of T cell factor transactivating complex
HIST1H2BK HIST2H2AB	PRC2 methylates histones and DNA
HIST1H2BK HIST2H2AB ASF1A	DNA damage/telomere stress-induced senescence
HIST1H2BK HIST2H2AB RFC3	Chromosome maintenance
HIST1H2BK HIST2H2AB	SIRT1 negatively regulates rRNA expression
HIST1H2BK HIST2H2AB	Activated PKN1 stimulates transcription of AR (androgen receptor)-regulated genes KLK2 and KLK3
HIST1H2BK POLR2K HIST2H2AB	Transcriptional regulation by small RNAs
PAX3 ELP4 HIST2H2AB HIST1H2BK	Histone acetyltransferases acetylate histones
HIST1H2BK POLR2K HIST2H2AB TWISTNB	Epigenetic regulation of gene expression
HIST1H2BK HIST2H2AB	Condensation of prophase chromosomes
HIST1H2BK HIST2H2AB	Nucleosome assembly