Table 2. Clinical and laboratory follow-up of the newborn.
Age | 0 | 4 d | 7 d | 10 d | 13 d | 17 d | 20 d | 22 d | 1 mo 5 d | 1 mo 17 d | 2 mo 5 d | 2 mo 11 d | 2 mo 25 d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GA | 36 + 3 | 38 + 5 | 3 d | 19 d | 25 d | 1 mo 9 d | |||||||
Weight (g) | 2,660 | 2,130 | 2,090 | 2,205 | 2,270 | 2,345 | 2,390 | 2,380 | 3,100 | 3,510 | 4,040 | ||
Height (cm) | 47.5 | 53.5 | 55 | ||||||||||
TSH (mUI/mL) | 0.027 | <0.015 | 15 | <0.01 | <0.01 | 0.33 | 629 | <0.01 | |||||
FT4 (ng/dL) | 5.59 | 6.37 | 5.07 | 3.63 | 3.22 | 3.48 | 3.03 | 2.27 | 1.0 | 0.7 | 0.4 | 0.54 | 1.7 |
T3 (ng/m L) | 3.54 | 2.88 | 3.32 | 3.89 | 4.1 | 3.6 | 2.0 | 1.1 | 0.9 | 129 ng/dL | |||
TRabs (UI/L) | 9.187 | 6.88 | 0.19 | ||||||||||
Therapy | Methimazole 0.5–0.5 mg (0.38 mg/kg/d) Propranolol 2–2 mg (1.5 mg/kg/d) |
↓Propranolol 1–1 mg due to bradycardia, start of ursodiol and vitamin E | ↑Methimazole 1–0.5 mg (0.7 mg/kg/d) Propranolol 2–2 mg |
↑Methimazole 1–1 mg (0.83 mg/kg/d) Propranolol 2–2 (1.67 mg/kg/d) |
Propranolol suspension, Ursodiol 25 mg c/8 h (20 mg/kg/d) | ↓Methimazole 1–0.5 mg (0.48 mg/kg/d), ursodiol, vitamin E suspension | ↓Methimazole 0.5–0.5 mg (0.28 mg/kg/d) | Methimazole suspension | LVT 25 µg (6 µg/kg/d) | LVT suspension |
Abbreviations: FT4, free thyroxine; GA, gestational age; LVT, levothyroxine; T3, triiodothyronine; TRAbs, thyrotropin receptor antibodies; TSH, thyroid-stimulating hormone.
Note: References values: TRAbs (NR <1.5), LVT (0.78–2.19), T3 (0.97–1.7), and TSH (0.9–7.7).