Table 4.
Change in echocardiographic parameters during the treatment period (n = 27)
| Parameter | Value at baseline | Value at discharge | Value change (baseline-discharge) | P-value |
|---|---|---|---|---|
| LA diameter PLAX (mm) | 54.81 ± 6.57 | 50.77 ± 6.32 | 4.04 | < 0.001 |
| LA area in AP4 (cm2) | 35.86 ± 9.11 | 32.47 ± 9.37 | 3.38 | < 0.001 |
| LVEDD in PLAX (mm) | 61± 11.41 | 58.35 ± 11.03 | 2.65 | < 0.001 |
| LVESD in PLAX (mm) | 48.35 ± 13.47 | 46.65 ± 13.27 | 1.69 | 0.002 |
| LVEDV (Simpson biplane method) (ml) | 179.08 ± 80.51 | 174.15 ± 80.03 | 4.92 | 0.307 |
| LVEF (Simpson biplane method) (%) | 34.73 ± 13.88 | 40.24 | 5.50 | < 0.001 |
| Mitral annular diameter in PLAX (mm) | 42.33 ± 6.63 | 39.72 ± 5.05 | 2.61 | < 0.001 |
| Mitral annular diameter in AP4 (mm) | 42.46 ± 4.99 | 39.67 ± 5.13 | 2.79 | < 0.001 |
| Mitral mean gradient (mmHg) | 2.25 ±1.31 | 1.81 ± 0.89 | 0.45 | 0.02 |
| Peak E-wave velocity (cm/s) | 122.83 ± 31.29 | 107.33 ± 23.61 | 15.50 | < 0.001 |
| E/A ratio | 0.95 ± 1.22 | 0.94 ± 1.16 | 0.004 | 0.98 |
| VC (mm) | 6.21 ± 1.48 | 5.26 ± 1.61 | 0.95 | < 0.001 |
| PISA MR radius (mm) | 7.84 ± 2.65 | 6.36 ± 2.25 | 1.04 | < 0.001 |
| MR VTI (cm) | 136.32 ± 24.67 | 136.37 ± 23.84 | -0.05 | 0.98 |
| MR V max (m/s) | 4.61 ± 0.63 | 4.53 ± 0.65 | 0.07 | 0.4 |
| MR EROA (cm2) | 0.37 ± 0.17 | 0.25 ± 0.16 | 0.11 | < 0.001 |
| MR volume (ml) | 44.92 ± 22.83 | 30.88 ± 18.77 | 14.04 | < 0.001 |
Data are expressed as the mean value ± standard deviation
AP4 apical four chambers view EROA-effective regurgitant orifice area, LA left atrium, LVEDD left ventricular end diastolic diameter, LVEDV left ventricular end diastolic volume, LVEF left ventricular ejection fraction, LVESD left ventricular end systolic diameter, LVESV left ventricular end systolic volume, MR mitral regurgitation, PISA proximal Isovelocity Surface Area, PLAX parasternal long axis view, VC vena contracta, VTI velocity time integral