Table 3.
Serotypes/serogroups of S. pneumoniae, H. influenzae, and N. meningitidis registered with the Nationwide Reference Laboratories in children in North Rhine-Westphalia (Germany), 2016–2023
| Pathogen | 2016–2021 | 2022–03/2023 | |
|---|---|---|---|
| S. pneumoniae | Serotype | n = 235 | n = 75 |
| Preventable with PCV13*a | 56 (24%) | 28 (37%) | |
| Preventable with PCV15*b | 65 (28%) | 29 (39%) | |
| Preventable with PCV20*c | 123 (52%) | 33 (44%) | |
| Preventable with PCV23*d | 134 (57%)** | 38 (51%) | |
| Non-vaccine-preventable | 100 (43%) | 37 (49%) | |
| H. influenzae | Serotype | n = 62 | n = 25 |
| b | 17 (27%) | 2 (8%) | |
| Non-vaccine preventable | 45 (73%) | 23 (92%) | |
| N. meningitidis | Serogroup | n = 98 | n = 18 |
| B | 79 (81%) | 13 (72%) | |
| C | 3 (3%) | 1 (6%) | |
| W | 4 (4%) | 0 (0%) | |
| X | 0 (0%) | 1 (6%) | |
| Y | 12 (12%) | 3 (17%) | |
| Serogroup missing | 1 (1%) | 0 (0%) | |
*aPCV13 serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 9 V, 14, 18C, 19A, 19F, 23F
*bPCV15 serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 9 V, 14, 18C, 19A, 19F, 22F, 23F, 33F
*cPCV20 serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 9 V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, 33F
*dPCV23 serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9 V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F
**One case with serotype 6A was preventable with PCV13, PCV15 or PCV20 but not with PCV23