Table 4.

National surveillance and multicenter study detection of pediatric severe and invasive bacterial infections between October 1st and December 31st of 2022 in North-Rhine Westphalia (Germany)

Pathogen	Captured by			Estimated number of non-captured cases	Estimated total number of cases
	NRL only	MC only	Overlap of NRL and MC
	N	n	n	n (95% CI)	n
S. pyogenes	18	58	5	138 (48–400)	214
S. pneumoniae	18	63	5	151 (52–437)	232
N. meningitidis	6	2	2	0 (0–0)a	6
H. influenzae	6	31b	2	58 (10–329)	95

NRL nationwide reference laboratory, MC multicenter study

^aExact estimate: 2.1E-11 (9.4E-12–4.6E-11)

^bPrimary and co-infections included