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. 2024 May 31;15:4644. doi: 10.1038/s41467-024-48991-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Replication organelles (ROs) comprise various RNA species (vgRNA, dsRNA) and proteins (RdRp, nsp3) organized by remodeled cellular ER membranes. Our data support a model which specifies the spatial organization of ROs at early (left panel) and late (right panel) stages of infection. Specific RNA and protein molecules are shown to be distinctly organized within the ROs. The replication and transcription of SARS-CoV-2 RNA occur within the double-membrane vesicles (DMVs) and vesicle packets (VPs) in proximity to RdRp.