Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 31;15:4653. doi: 10.1038/s41467-024-47547-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Patient primary tumors (n patients = 43; n tumors = 46) are split based on histology and subsequently whether a PDX model was generated from any tumor region (PDX) or not (no PDX). Within each category, tumors are ordered according to their total mutation burden. Top panel: total number of coding and non-coding mutations including single nucleotide variants (SNVs), dinucleotide and indel alterations. Bars are colored by the clonality status of alterations. Second panel: proportion of truncal and subclonal mutations. Third panel: proportion of copy number alterations that were truncal or subclonal. Fourth panel: proportion of mutational signatures as estimated across all mutations. Bottom panel: driver alterations on a per tumor basis. The genes shown are mutated in more than three tumors in this patient cohort. Mutations are colored by the clonal status of alterations. LUAD—lung adenocarcinoma; LUSC—lung squamous cell carcinoma; CN—copy number; MMR—mismatch repair.