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. 2024 May 31;15:4653. doi: 10.1038/s41467-024-47547-3

Fig. 6. On-going evolution in PDX models.

Fig. 6

A Overview of engraftment patterns relative to the primary tumor of initial (P0) and established (P3) PDX models. B, C Comparison of mutational distance (B) and copy number distance (C) between P0 and matched P3 PDX models, P0 PDX models and the matched region of origin, and P3 PDX models and the matched region of origin (n = 32 comparisons per group). D The proportion of the aberrant genome for matched primary tumor region of origin, P0 PDX model and P3 PDX model samples (n = 32 samples per group). E Proportion of the genome subject to loss of heterozygosity (LOH) for matched primary tumor region of origin, P0 PDX model and P3 PDX model samples (n = 32 samples per group). B–E The box plots represent the upper and lower quartiles (box limits), the median (center line) and the whiskers span 1.5*IQR. Lines indicate sample matching. Two-sided Wilcoxon signed rank test, p values as indicated. LUAD—lung adenocarcinoma; LUSC—lung squamous cell carcinoma.