Figure 2.
Metabolic intermediates are cofactors for the chromatin‐modifying enzymes. (a) Metabolic intermediates are essential cofactors for chromatin modifying enzymes. (b) Acetyl‐coenzyme A production can be catalyzed from pyruvate, acetate and citrate by different enzymes. CoA, coenzyme A; FADH2, rlavin adenine dinucleotide; HAT, histone acetyltransferases; HDM, histone demethylase; HTM, histone methyltransferase; NAD+, nicotinamide adenine dinucleotide; NAM, nicotinamide; OAADPR, O‐acetyl‐ADP‐ribose; SAH, S‐adenosylhomocysteine; SAM, S‐adenosylmethionine; α‐KG, α‐ketoglutarate. Created with BioRender.com