Table 2. Slopes of Change in Hemoglobin and Iron Indices.
| Model | Slope estimate (SE)a | P value |
|---|---|---|
| Cohort with normal kidney functionb | ||
| Hemoglobin, unadjusted g/dL | ||
| Daily | 0.27 (0.00) | <.001 |
| MDD vs daily | 0.08 (0.03) | <.001 |
| ADD vs daily | −0.01 (0.01) | .38 |
| Hemoglobin, adjusted g/dL | ||
| Daily | 0.27 (0.00) | <.001 |
| MDD vs daily | 0.08 (0.00) | <.001 |
| ADD vs daily | −0.01 (0.01) | .37 |
| Ferritin, unadjusted ng/mL | ||
| Daily | 3.07 (0.30) | <.001 |
| MDD vs daily | 3.04 (0.37) | <.001 |
| ADD vs daily | −2.70 (1.43) | .06 |
| Ferritin, adjusted ng/mL | ||
| Daily | 3.07 (0.30) | <.001 |
| MDD vs daily | 3.03 (0.37) | <.001 |
| ADD vs daily | −2.70 (1.43) | .06 |
| TIBC, unadjusted µg/dL | ||
| Daily | −6.77 (0.24) | <.001 |
| MDD vs daily | −5.09 (0.31) | <.001 |
| ADD vs daily | 3.69 (1.19) | .002 |
| TIBC, adjusted µg/dL | ||
| Daily | −6.79 (0.24) | <.001 |
| MDD vs daily | −5.06 (0.31) | <.001 |
| ADD vs daily | 3.68 (1.19) | .002 |
| ISAT, unadjusted % | ||
| Daily | 1.97 (0.05) | <.001 |
| MDD vs daily | 0.52 (0.06) | <.001 |
| ADD vs daily | −0.27 (0.22) | .21 |
| ISAT, adjusted % | ||
| Daily | 1.97 (0.05) | <.001 |
| MDD vs daily | 0.52 (0.06) | <.001 |
| ADD vs daily | −0.26 (0.22) | .24 |
| Cohort with chronic kidney diseasec | ||
| Hemoglobin, unadjusted g/dL | ||
| Daily | 0.19 (0.00) | <.001 |
| MDD vs daily | 0.06 (0.00) | <.001 |
| ADD vs daily | −0.03 (0.01) | .02 |
| Hemoglobin, adjusted g/dL | ||
| Daily | 0.19 (0.00) | <.001 |
| MDD vs daily | 0.06 (0.00) | <.001 |
| ADD vs daily | −0.03(0.14) | .02 |
| Ferritin, unadjusted ng/mL | ||
| Daily | 3.11 (0.47) | <.001 |
| MDD vs daily | 3.36 (0.61) | <.001 |
| ADD vs daily | −1.41 (2.13) | .51 |
| Ferritin, adjusted ng/mL | ||
| Daily | 3.11 (0.47) | <.001 |
| MDD vs daily | 3.36 (0.61) | <.001 |
| ADD vs daily | −1.37 (2.13) | .52 |
| TIBC, unadjusted µg/dL | ||
| Daily | −5.48 (0.28) | <.001 |
| MDD vs daily | −3.85 (0.37) | <.001 |
| ADD vs daily | 2.23 (1.16) | .06 |
| TIBC, adjusted µg/dL | ||
| Daily | −5.50 (0.28) | <.001 |
| MDD vs daily | −3.86 (0.37) | <.001 |
| ADD vs daily | 2.17 (1.16) | .06 |
| ISAT, unadjusted % | ||
| Daily | 1.72 (0.05) | <.001 |
| MDD vs daily | 0.43 (0.07) | <.001 |
| ADD vs daily | 0.02 (0.21) | .91 |
| ISAT, adjusted % | ||
| Daily | 1.73 (0.05) | <.001 |
| MDD vs daily | 0.43 (0.07) | <.001 |
| ADD vs daily | 0.04 (0.21) | .83 |
Abbreviations: ADD, alternate day dose; ISAT, iron saturation; MDD, multiple doses per day; TIBC, total iron binding capacity.
Conversion factors: To convert ferritin to micrograms per liter, multiply by 1; hemoglobin to grams per liter, multiply by 10; TIBC to micromoles per liter, multiply by 0.179.
Slopes represent the 30-day change for each laboratory value.
Cohort with normal kidney function was adjusted for Charslon Comorbidity Index, body mass index, age, sex, diabetes, chronic obstructive pulmonary disease, anticoagulants, antiplatelets, proton-pump inhibitors, type of oral iron, sleep apnea, and smoking status.
Cohort with chronic kidney disease was adjusted for Charlson Comorbidity Index, body mass index, age, chronic obstructive pulmonary disease, anticoagulants, antiplatelets, type of oral iron, angiotensin converting enzymes and angiotensin receptor blockers, current or former smoking, chronic kidney disease staging, and sleep apnea.