Box 6.

Recommendation and Suggestion for first-line monotherapy of hypertension

1- It is recommended for people with hypertension and without comorbidities who need pharmacotherapy, the first-line Medicine should be one of antihypertensive drugs that consists of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs), thiazide and thiazide-like agents, and calcium channel blockers (CCBs) 2- It is recommended that in people over 75 years of age with hypertension, the first medicinal treatment should be the use of one of the CCBs or thiazide and thiazide-like agents 3- It is recommended to use one of the medicines in the class of ACEIs/ARBs, CCBs, or thiazide and thiazide-like agents in patients with hypertension and diabetes mellitus (without albuminuria) 4- It is recommended that in patients suffering from hypertension and CKD (who have albuminuria more than 30 mg/g Cr), the first-line therapy should be one of the medications in the medication class of ACEIs or ARB 5- It is recommended that in patients with hypertension and a history of stroke, the first pharmaceutical treatment should be the use of one of the medications in the medication class of ACEIs/ARBs, thiazide and thiazide-like agents, and if not effective or side effects occure, one of the CCB drugs should be used 6- It is recommended to use one of ACEIs or ARBs or beta blockers in patients with hypertension and coronary artery diseases 7- It is suggested to use one of the long-acting CCB drugs in patients with hypertension and coronary artery disease if beta-blockers are not effective or are contraindicated 8- It is recommended that in patients suffering from hypertension and HF, the first-line treatment should be one of the ACEIs or ARBs drugs