Box 7.

Recommendation and Suggestion for first-line combined drug therapy of hypertension

1- It is recommended for people with hypertension who prescribed a combination pill of different classes of antihypertensive drugs, as the first-line treatment, a combination pill including ACEIs/ARBs, CCBs, diuretics (thiazide/thiazide like diuretics), to be used to increase compliance and adherence to treatment 2- In patients with hypertension and diabetes mellitus who need drug therapy, a combination therapy of ACEIs/ARBs and CCBs or ARBs/ACEIs and thiazide/thiazide like diuretics is recommended 3- In patients with hypertension and a history of stroke, a combination therapy of ACEIs/ARBs and thiazide/thiazide like diuretics or ACEIs/ARBs and CCBs is suggested 4- In patients with hypertension and coronary artery diseases, a combination therapy should be recommended based on the patient's condition using ACEIs/ARBs and beta blockers or ACEIs/ARBs and CCBs 5- It is recommended that for patients suffering from hypertension and HF without a reduction of ejection fraction, a combination therapy of one of the ACEIs/ARBs drugs and beta blockers be used 6- In hypertensive patients whose DBP is high with or without SBP, it is suggested to adopt a combination therapy using ACEIs/ARBs and CCBs or ACEIs/ARBs and diuretic