Table 8.

Potential factors for non-improvement at 7 days after starting treatment and for non-reporting of primary cases newly diagnosed between 2010 and 2020 in public hospitals in Mainland Portugal, according to logistic regression models to estimate crude and adjusted odds ratio values

a)	Potential Risk Factor	Univariate			Multivariate
		% in Sample	Crude OR	95% CI	Adjusted OR	95% CI	P-value
Non-improvement at 7 days	Male sex	68.5	3.88	[0.85–17.88]	2.66	[0.49–14.41]	0.257
	Immunosuppressed	62.4	11.36	[1.47–90.91]	5.71	[0.65–50.0]	0.115
	Chronic organ dysfunction	24.6	2.72	[0.93–7.94]	2.79	[0.65–12.05]	0.168
	Acute kidney injury	15.2	3.82	[1.24–11.76]	1.37	[0.32–5.92]	0.670
	Leucocyte count < 1500/µl	37.7	3.86	[1.24–12.01]	2.47	[0.62–9.76]	0.199
	CRP > 100 mg/L	43.6	2.69	[0.93–7.75]	5.18	[1.19–22.22]	0.028
	Coinfection/superinfection	41.5	3.17	[1.03–9.80]	1.62	[0.32–5.95]	0.468
	Constant				77.713		< 0.001
	Hosmer and Lemeshow Test				0.758
b)	Potential Risk Factor	Univariate			Multivariate
		% in Sample	Crude OR	95% CI	Adjusted OR	95% CI	P-value
Non-reporting	Age > 5 years old	17.5	2.78	[1.22–6.32]	4.07	[1.19–13.93]	0.026
	Immunosuppressed	60.8	2.11	[1.14–3.92]	1.15	[0.46–2.87]	0.758
	Region of hospital AML or Norte	64.9	3.22	[1.71–6.09]	3.91	[1.74–8.75]	< 0.001
	Secondary center	50.3	2.02	[1.13–3.60]	2.09	[1.03–4.27]	0.042
	Non-improvement at 7 days	11.4	1.66	[0.60–4.63]	1.56	[0.50–4.86]	0.446
	Constant				0.345		0.310
	Hosmer and Lemeshow Test				0.354

OR Odds ratio, CI Confidence interval, CRP C-reactive protein, AML Área Metropolitana de Lisboa