Table 2.

Fluoride exposed disturbed VSMCs energy metabolism in negative ion mode

SubClass	Name	HMDB	VIP	p-value
Amino acids, peptides, and analogues	DL-glutamine		5.781	< 0.001
	Glutamic acid	HMDB0000148	4.836	0.004
	Ectoine		3.422	0.047
	D-proline	HMDB0003411	2.668	< 0.001
	L-threonine	HMDB0004041	2.240	0.004
	L-aspartic acid	HMDB0062186	1.980	0.013
	D-2-aminobutyric acid	HMDB0000452	1.542	0.005
	Lysine	HMDB0003405	1.534	0.005
	Histidine	HMDB0000177	1.233	0.033
	L-cysteine-glutathione disulfide		1.209	< 0.001
	Glycine	HMDB0000123	1.170	< 0.001
	Phenaceturic acid	HMDB0000821	1.074	0.041
	Ser-Ser		1.071	< 0.001
Carbohydrates and carbohydrate conjugates	Xylitol	HMDB0002917	3.841	< 0.001
	L-iditol	HMDB0011632	3.705	< 0.001
	D-mannose 6-phosphate	HMDB0001078	2.256	0.002
	Cyclic adenosine diphosphate ribose		1.903	< 0.001
	N-Acetylglucosamine 1-phosphate	HMDB0001367	1.783	< 0.001
	N-acetyl-d-galactosaminitol		1.343	< 0.001
	N-acetyl-d-glucosamine 6-phosphate	HMDB0001062	1.332	< 0.001
Fatty acids and conjugates	Cis-7,10,13,16-docosatetraenoic acid	HMDB0002226	4.202	0.018
	5-heptenoic acid, 7-[(1r,2r,3 s,5 s)-2-[(1e,3 s)-3-(2,3-dihydro-1 h-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5z)-		3.048	< 0.001
	Dodeca-2(e),4(e)-dienoic acid		1.911	0.007
	Adipic acid	HMDB0000448	1.814	< 0.001
	8,11-tridecadienoic acid, 13-(3-pentyl-2-oxiranyl)-, (8z,11z)-		1.183	0.023

VIP, variable important in projection. P < 0.05 versus the control group (n = 6)