Table 7.
Incremental HCRU costs in CDI patients during 12-months follow-up stratified by number of rCDIs
| Incremental costs during follow-up (€) | Non-CDI patientsa | All CDI patients (matched cohort) |
Non-rCDI patients (0 rCDI) | Patients with 1 rCDI | Patients with 2 rCDIs | Patients with ≥ 3 rCDIs | Patients with ≥ 1 rCDIs |
|---|---|---|---|---|---|---|---|
| Total number of patients, N | 16,845 | 5,618 | 4,552 | 803 | 185 | 78 | 1,066 |
| Incremental costs of hospitalisations | |||||||
| Sum | Ref. | 14,222,622 | 8,290,958 | 3,799,936 | 1,409,363 | 722,364 | 5,931,663 |
| Mean (SD) | Ref. | 2,531.62 (16,640.40) | 1,821.39 (16,057.35) | 4,732.17 (18,225.65) | 7,618.18 (19,349.17) | 9,261.08 (20,431.98) | 5,564.41 (18,635.09) |
| Incremental costs of outpatient visits | |||||||
| Sum | Ref. | 2,137,756 | 1,734,505 | 188,986 | 95,724 | 118,542 | 403,251 |
| Mean (SD) | Ref. | 380.52 (4,104.82) | 381.04 (4,114.01) | 235.35 (3,214.47) | 517.42 (3,993.73) | 1,519.77 (9,027.18) | 378.28 (4,067.28) |
| Incremental costs of pharmacological treatments (outpatient) | |||||||
| Sum | Ref. | 2,075,799 | 1,712,699 | 247,582 | 71,063 | 44,455 | 363,100 |
| Mean (SD) | Ref. | 369.49 (7,169.23) | 376.25 (7,248.10) | 308.32 (7,030.12) | 384.13 (5,874.35) | 569.93 (6,858.46) | 340.62 (6,825.36) |
| Incremental costs of diagnosis tests | |||||||
| Sum | Ref. | 183,979 | 133,571 | 39,812 | 5,793 | 4,802 | 50,408 |
| Mean (SD) | Ref. | 32.75 (244.99) | 29.34 (244.24) | 49.58 (268.84) | 31.32 (158.48) | 61.57 (188.71) | 47.29 (247.80) |
| Incremental costs of medical devices | |||||||
| Sum | Ref. | 2,633,573 | 2,203,230 | 207,626 | 139,218 | 83,499 | 430,343 |
| Mean (SD) | Ref. | 468.77 (4,035.98) | 484.01 (4,359.15) | 258.56 (1,806.48) | 752.53 (3,151.74) | 1,070.50 (2,528.95) | 403.70 (2,169.26) |
| Incremental costs of medical transportations | |||||||
| Sum | Ref. | 1,988,379 | 1,433,702 | 355,927 | 122,402 | 76,348 | 554,677 |
| Mean (SD) | Ref. | 353.93 (2,665.55) | 314.96 (2,781.14) | 443.25 (1,966.70) | 661.63 (2,054.19) | 978.82 (3,160.15) | 520.34 (2,094.55) |
| Total incremental costs | |||||||
| Sum | Ref. | 23,040,261 | 15,355,011 | 4,803,207 | 1,845,284 | 1,036,759 | 7,685,250 |
| Mean (SD) | Ref. | 4,101.15 (22,108.35) | 3,373.24 (22,068.18) | 5,981.58 (21,825.62) | 9,974.51 (21,223.71) | 13,291.78 (24,434.36) | 7,209.43 (22,020.12) |
CDI, Clostridioides difficile infection; rCDI, recurrent CDI infection; SD, standard deviation. All HCRU captured for 12-month follow-up after index date. Costs are expressed in euros, inflated to 2020 rates. Total costs of medical procedures were not presented, since there are no individual values recorded in the BKK database
a Costs in CDI patients were compared with costs among the respective matched non-CDI patients according to the number of rCDIs. As matching of CDI patients and control non-CDI patients is usually not 1:1 (up to 3 non-CDI patients will be matched to a CDI patient), total costs for non-CDI patients were divided by the number of non-CDI patients per case before deriving the incremental difference