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. 2024 Jun 1;43:156. doi: 10.1186/s13046-024-03083-y

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Fzd7-KD and ILK inhibition activate pro-apoptotic signaling in OC spheroids treated with carboplatin. A, B WB for Fzd7, p-ILK^Ser246, ILK, p-AKT^Ser473, AKT, p-Bad^Ser136, Bad, Ccaspase-3, caspase-3, and GAPDH in HGSOC OVCAR-3 cells grown as spheroids and treated with DMSO control or cpd-22 in combination or not with carboplatin (double IC₅₀) (left panel). Densitometry quantifies Fzd7 expression levels and p-ILK^Ser246/ILK, p-AKT^Ser473/AKT, p-Bad^Ser136/Bad, and Ccaspase-3/caspase-3 ratio (right panel) (N = 3; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001). C WB for Fzd7, p-ILK^Ser246, ILK, p-AKT^Ser473, AKT, p-Bad^Ser136, Bad, Ccaspase-3, caspase-3, and GAPDH in HGSOC shCtr or shFzd7 (clone #2) OVCAR-3 cells grown as spheroids and treated or not with carboplatin (double IC₅₀) (left panel). Densitometry quantifies Fzd7 expression levels and p-ILK^Ser246/ILK, p-AKT^Ser473/AKT, p-Bad^Ser136/Bad, and Ccaspase-3/caspase-3 ratio (right panel) (N = 3; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001)