Table 1.
Demographic and Ocular Characteristics of Pachychoroid and Conventional GA Groups
| Characteristics | Pachychoroid GA | Conventional GA | P Value |
|---|---|---|---|
| Patients, n | 38 | 135 | |
| Age (median, range), years | 70.3 ± 7.5 (70, 56–86) | 78.7 ± 8.3 (80, 53–97) | <0.001 |
| Sex, n, males (%) | 34 (89.5) | 75 (55.6) | <0.001 |
| Smoking status, n, current or former (%); n = 151 | 26 (89.7) | 64 (52.5) | <0.001 |
| Axial length (median), mm; n = 123 | 23.4 ± 0.9 (23.3) | 23.5 ± 0.9 (23.5) | 0.752 |
| BCVA, logMAR (Snellen equivalent) | 0.15 ± 0.27 (20/28) | 0.40 ± 0.45 (20/50) | 0.002 |
| CMT (median, range), μm | 143.6 ± 63.8 (149.5, 7.0–242.0) | 145.3 ± 74.5 (151, 6.0–617.0) | 0.283∗ |
| SFCT (median, range), μm | 312.4 ± 116.0 (322, 140.5–622.0) | 161.6 ± 74.4 (153, 36.5–414.0) | <0.001† |
| GA area (median, range), mm2 | 0.59 ± 0.76 (0.28, 0.05–2.81) | 3.76 ± 4.26 (2.41, 0.05–24.88) | <0.001 |
| GA area (SQRT) (median, range), mm | 0.66 ± 0.40 (0.52, 0.23–1.68) | 1.66 ± 1.01 (1.55, 0.23–4.99) | <0.001 |
| GA location, central/non-central | 16/22 | 74/61 | 0.199 |
| GA type, unifocal/multifocal | 36/2 | 67/68 | <0.001 |
| Drusen, n, present (%) | 0 (0) | 115 (85.2) | <0.001 |
| Reticular pseudodrusen, n, present (%) | 0 (0) | 73 (54.1) | <0.001 |
| Fellow eye status, GA/neovascular AMD/intermediate AMD/no AMD‡ | 1/8/0/29 | 61/45/22/4 | <0.001 |
AMD = age-related macular degeneration; BCVA = best-corrected visual acuity; CMT = central macular thickness; GA = geographic atrophy; logMAR = logarithm of the minimum angle of resolution; n = number of patients; SFCT = subfoveal choroidal thickness; SQRT = square-root transformation.
∗
Age-adjusted.
†
Age and sex-adjusted.
‡
Three patients lacked information on their fellow eyes due to phthisis.