Alignment of amino acid sequences of the C, D, and E domains of the parental strains CFI, KCD, NADC, and URB. The domains are marked by vertical lines, as is the border between the left and right halves of the E region. The amino acid residues are numbered from the start of translation of the capsid protein of the URB strain. Arrows indicate the amino acid residues that were identified as changed by Tohya et al. (29) in MAb neutralization-resistant variants of FCV. The underlined residues are those that make up the highly conserved central core region.