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delivery of mrna for macrophage polarization and synergistic immunotherapy. a) schematic representation of mrna/lnp. b,c) mrna expression of classic m1 (b) and m2 (c) markers in hcc tumor tissues 48 h after systemic administration of mrna/lnp. d) percentage of cd8+ t cells in cd3+ t cells. e) percentage of nk cells in cd45+cd3- cells. immune cells derived from mice 48 h after injection with mrna/lnp.
