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a,b) schematic of lipid nanoparticle and nucleoside modified mrna encoding influenza antigens. c) sera were collected from mice 28 days after mrna-lnp vaccination. antibodies against corresponding antigens were measured via elisa. d-f) body weight loss over time of mice challenged with d) 5 ld50, e) 50 ld50 or f) 500 ld50 of h1n1pdm influenza. (n 5 per group). adapted with permission from ref. 138. copyright 2020, asgct.
