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. Author manuscript; available in PMC: 2024 Jun 2.
Published in final edited form as: Nat Immunol. 2023 Jul 24;24(9):1415–1422. doi: 10.1038/s41590-023-01569-z

Fig. 2 |. LAG-3 signaling.

Fig. 2 |

The ‘EP’, KIEELE’ and ‘pS454/FxxL’ motifs are highly conserved motifs within the cytoplasmic tail of LAG-3. The ‘EP’ motif causes Lck to dissociate from CD4/CD8 by lowering the local pH. The mechanisms of action for ‘KIEELE’ and ‘pS454/FxxL’ are unknown. sLAG3, soluble LAG-3; MHC II, MHC class II.