Table 2. The main pharmacokinetic parameters of tramadol and O-desmethyl tramadol in group C and group D.

Parameters	Tramadol		O-desmethyl tramadol
	Group C	Group D	Group D	Group D
AUC(0−t) (µg/L h)	777.09 ± 232.62	1,647.49 ± 474.03**	1,172.61 ± 170.75	1,226.57 ± 111.61
AUC(0−∞) (µg/L h)	790.48 ± 226.30	1,652.18 ± 474.39**	1,175.84 ± 170.44	1,251.86 ± 103.71
t1/2z (h)	6.69 ± 5.14	2.74 ± 0.56	2.86 ± 0.71	4.06 ± 0.91*
Tmax (h)	1.60 ± 0.55	0.90 ± 0.65	1.20 ± 0.45	0.90 ± 0.65
Vz/F (L/kg)	306.53 ± 308.69	51.44 ± 19.09	72.54 ± 25.45	94.72 ± 26.39
CLz/F (L/h/kg)	27.53 ± 9.92	12.81 ± 3.14**	17.31 ± 2.60	16.07 ± 1.36
Cmax (µg/L)	245.83 ± 57.58	294.28 ± 85.18	292.40 ± 55.09	181.96 ± 65.78*

Notes.

Group C: Tramadol single-use group; Group D: Tramadol with crizotinib (multiple dose for 7 days).

*P < 0.05, **P < 0.01, ***P < 0.001 in comparison with the control group.

AUC

area under the blood concentration–time curve

t_1/2z

elimination half time

T_max

peak time

V_z/F

apparent volume of distribution

CL_z/F

blood clearance

C_max

maximum blood concentration