Figure 2.

Associations of genetic scores for (A) PCSK9 and (B) low-density lipoprotein cholesterol with risk of vascular and non-vascular disease endpoints. Odds ratios are estimated using logistic regression of the weighted PCSK9 and low-density lipoprotein cholesterol genetic scores, each scaled to the effect corresponding to a predicted 1 SD lowering of low-density lipoprotein cholesterol, calculated as the inverse-variance-weighted mean of region-specific estimates with adjustment for age, age-squared, sex, ascertainment, and region-specific principal components. CI, confidence interval; COPD, chronic obstructive pulmonary disease; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio.