Table 1.
Baseline characteristics of the population-representative subset of genotyped China Kadoorie Biobank participants, divided into four categories according to their PCSK9 genetic score
| PCSK9-GS range | <1.33 | 1.33 to <1.43 | 1.43 to <1.53 | ≥1.53 | P |
|---|---|---|---|---|---|
| Characteristic | (n = 4557) | (n = 20 274) | (n = 39 786) | (n = 6297) | |
| PCSK9-GS, mean (SD) | 1.11 (0.24) | 1.40 (0.01) | 1.49 (0.02) | 1.57 (0.03) | — |
| LDL-C (mmol/L), mean (SD)a | 2.13 (0.65) | 2.32 (0.65) | 2.39 (0.71) | 2.39 (0.72) | 1.6 × 10−8 |
| Age (years), mean (SD) | 52.2 (10.8) | 52.0 (10.7) | 52.2 (10.7) | 52.3 (10.8) | 0.23 |
| Female, % | 59.9 | 59.9 | 59.9 | 58.0 | 0.03 |
| Urban region, % | 45.3 | 45.6 | 46.1 | 45.1 | 0.26 |
| Height (cm), mean (SD) | 159.1 (8.2) | 158.8 (8.3) | 158.7 (8.3) | 158.9 (8.4) | 0.03 |
| BMI (kg/m2), mean (SD) | 23.9 (3.5) | 23.8 (3.4) | 23.8 (3.4) | 23.9 (3.5) | 0.03 |
| Waist/hip ratio, mean (SD) | 0.88 (0.07) | 0.88 (0.07) | 0.88 (0.07) | 0.88 (0.07) | 0.02 |
| SBP (mmHg), mean (SD) | 131.7 (21.4) | 131.3 (21.3) | 131.5 (21.5) | 131.9 (21.1) | 0.14 |
| DBP (mmHg), mean (SD) | 78.3 (11.2) | 77.9 (11.2) | 78.0 (11.3) | 78.2 (11.1) | 0.09 |
| Physical activity (MET h/d), mean (SD) | 20.5 (14.1) | 20.8 (14.0) | 20.5 (14.0) | 20.7 (14.1) | 0.10 |
| High school or higher education, % | 21.3 | 20.6 | 21.4 | 20.0 | 0.02 |
| Household income ≥20 000 yuan, % | 39.6 | 40.5 | 40.0 | 39.8 | 0.60 |
| Current regular alcohol drinking, % | 15.8 | 15.3 | 15.4 | 16.2 | 0.31 |
| Current regular smoker, % | 25.0 | 26.0 | 25.7 | 27.1 | 0.06 |
| Stroke/TIA,a % | 1.6 | 1.7 | 1.7 | 1.2 | 0.04 |
| Coronary heart disease,b % | 3.7 | 3.4 | 3.7 | 3.5 | 0.42 |
| Hypertension, % | 12.6 | 11.4 | 11.6 | 11.3 | 0.14 |
| Diabetes,c % | 6.1 | 5.9 | 6.2 | 6.2 | 0.65 |
| Taking statins, % | 1.8 | 1.6 | 1.9 | 2.4 | 0.50 |
BMI, body mass index; DBP, diastolic blood pressure; LDL-C, low-density lipoprotein cholesterol; MET, metabolic equivalent of task; PCSK9-GS, PCSK9 genetic score; SBP, systolic blood pressure; TIA, transient ischaemic attack.
aResults for 4181 members of the population-representative subset with LDL-C measurements.
bSelf-reported physician diagnosed.
cSelf-reported physician diagnosed or screen-detected at baseline.