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. 2024 Apr 10;27(6):109707. doi: 10.1016/j.isci.2024.109707

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Subcluster analysis demonstrated heterogeneity of synovial macrophage and dendritic cell (DC) populations in the integrated synovial single-cell map dataset from 25 fresh-dissociated synovial biopsies of patients with inflammatory arthritis

(A) UMAP of 3 dendritic cell (DC) clusters and nine synovial macrophage clusters colored by cell cluster.

(B) Bar plots of relative abundances of three DC and nine synovial macrophage clusters across 25 patient samples colored by cell cluster.

(C) The proportion of three DC and nine macrophage clusters across 25 synovial tissue samples from patients with inflammatory arthritis. The box plot visualises 5 summary statistics: the median; two hinges, corresponding to the first and the third quartiles, two whiskers. The upper (lower) whisker extends from the hinge to the largest (smallest) value no further then 1.5 ∗ interquartile range from the hinge. Individual dots represent data from different samples.

See also Figures S8–S10 and S15.