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. 2024 Apr 10;27(6):109707. doi: 10.1016/j.isci.2024.109707

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Single-cell reference map unveiled synovial cell composition in the fresh-dissociated human synovium in inflammatory arthritis

A UMAP of annotated 12 lymphoid, 14 myeloid and 16 stromal cell synovial cell clusters and subclusters showing extensive cellular heterogeneity of the human synovium in inflammatory arthritis. Cluster annotations are based on the analysis of the main cell types and the subcluster analysis of synovial T-cells/natural killer (NK) cells/innate lymphoid cells (ILC), fibroblast, macrophage, dendritic cell (DC) and endothelial cell populations. The integrated scRNA-seq data are derived from 25 synovial tissue samples from patients with different types of inflammatory arthritis (see STAR Methods for details). See also Figures S8–S10.