Table 3.
Linear regression model of factors associated with health-related quality of life (N = 570).
| Linear regression for PCS | Linear regression for MCS | |||
|---|---|---|---|---|
| Univariable β [95% CI] | Multivariable β [95% CI] | Univariable β [95% CI] | Multivariable Ψ β [95% CI] | |
| Sex, female | −2.22 [−3.86; −0.57] | −2.17 [−3.65; −0.69] | −0.73 [−2.55; 1.08] | |
| Age > 35 years | −3.75 [−5.29; −2.22] | −1.69 [−3.28; −0.09] | 0.80 [−0.92; 2.52] | |
| Born in France | 0.79 [−0.73; 2.32] | 1.43 [−0.24; 3.10] | ||
| Living in couple | −1.41 [−2.99; 0.17] | 0.72 [−1.01; 2.45] | ||
| Child(ren) with SCD | 2.73 [−0.58; 6.04] | −0.04 [−3.75; 3.67] | ||
| Secondary or high school completed | 5.70 [3.63; 7.77] | 4.36 [2.41; 6.31] | 0.27 [−2.06; 2.60] | |
| Self-perceived financial situation Unstable Moderate Stable |
0 2.27 [−0.01; 4.54] 4.99 [2.92; 7.06] |
0 0.36 [−1.73; 2.44] 2.85 [0.94; 4.76] |
0 1.84 [−0.66; 4.35] 6.46 [4.18; 8.73] |
0 1.07 [−1.42; 3.56] 4.95 [2.65; 7.26] |
| Professionally active | 2.24 [0.71; 3.77] | 2.88 [1.20; 4.55] | ||
| Relatives’ support | 4.15 [1.07; 7.24] | 6.95 [3.60; 10.30] | 5.27 [1.92; 8.62] | |
| Hospitalization for VOC or ACS* | −3.83 [−5.31; −2.34] | −2.58 [−3.93; −1.22] | −3.16 [−4.80; −1.52] | −2.38 [−3.99; −0.77] |
| Admission in intensive care unit* | −3.63 [−5.52; −1.74] | −2.23 [−4.32; −0.14] | ||
| Surgery, prosthesis or bone marrow transplant | −2.91 [−4.45; −1.36] | −0.28 [−2.00; 1.43] | ||
| History of blood transfusion* | −2.36 [−3.94; −0.79] | −0.80 [−2.53; 0.94] | ||
| Follow-up for other disease | −1.91 [−3.80; −0.01] | −0.73 [−2.81; 1.36] | ||
| SCD-related treatment** | −5.99 [−7.76; −4.22] | −1.44 [−3.44; 0.57] | ||
| Hydroxycarbamide use | 1.63 [−0.15; 3.40] | 2.02 [0.01; 4.03] | ||
| Oxygen therapy | −5.36 [−7.85; −2.87] | −3.20 [−5.56; −0.85] | −1.39 [−4.26; 1.48] | |
| Use of painkillers | −2.87 [−4.53; −1.20] | −1.61 [−3.16; −0.06] | −2.77 [−4.66; −0.88] | |
| Psychological follow-up | −3.86 [−5.46; −2.25] | −2.13 [−3.59; −0.67] | −3.30 [−5.07; −1.54] | −2.54 [−4.28; −0.80] |
| History of femoral osteonecrosis | −4.61 [−6.33; −2.89] | −3.09 [−4.64; −1.53] | −0.06 [−1.98; 1.86] | |
| History of splenic sequestration | −2.11 [−4.46; 0.25] | −0.24 [−2.83; 2.35] | ||
| Chronic complications*** | −4.43 [−6.30; −2.57] | −2.33 [−4.04; −0.62] | −2.17 [−4.25; −0.09] | |
PCS = physical component summary; MCS = mental component summary; SCD = sickle cell disease; VOC = vaso-occlusive crisis; ACS = acute chest syndrome; Ψ: adjusted for sex and age. * In the 12 last months. ** SCD-related treatment included hydroxycarbamide, oxygen therapy, or painkillers. *** Chronic complications: Pulmonary hypertension, cerebral vasculopathy, heart failure, renal insufficiency, retinopathy, skin ulcer, severe anemia.