Table 1. PICOS criteria for study determination.

Parameters	Description
Population	Peri-menopausal and/or post-menopausal female subjects suffering from climacteric symptoms
Intervention	Nutraceutical/dietary supplement/herbal supplement/medicinal food containing R. rhaponticum root extract (either alone or in combination)
Comparison	Either placebo or any supplement without R. rhaponticum root extract (either alone or in combination)
Outcomes	Efficacy of supplement evaluated using the Menopause Rating Scale score
Study design	Randomized, controlled clinical study with parallel or cross-over design